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Important information about Xenical

Xenical may decrease your body's absorption of some fat-soluble vitamins. To ensure adequate nutrition, your doctor may recommend taking a multivitamin that contains vitamins D, E, K, and beta-carotene. Take your vitamin supplement once a day, at least 2 hours before or after a dose of Xenical.

Do not take more of this medication than has been prescribed for you. Doses greater than 120 mg three times a day have not been shown to provide any additional weight-loss benefit.

What is Xenical?

Xenical blocks some of the fat that you eat from being absorbed by your body.

Xenical is used in the management of obesity including weight loss and weight maintenance when used with a reduced-calorie diet.

Xenical may also be used for purposes other than those listed in this medication guide.

How should I take Xenical?

Take Xenical exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water.

Xenical is usually taken with each main meal that contains fat. Xenical can be taken during meals or up to one hour after a meal.

Each time you take Xenical, your meal should contain no more than about 30% of calories from fat. Evenly divide your daily intake of fat, carbohydrates, and protein over three main meals a day. Talk to your doctor about following a healthy eating plan.

If you miss a meal, or if you have a meal without fat, you can skip your dose of Xenical for that meal also.

If Xenical is taken with any one meal that is very high in fat, there is an increased chance of digestive side effects.

Do not take more of this medication than has been prescribed for you. Doses greater than 120 mg three times a day have not been shown to provide an additional weight-loss benefit.

Store Xenical at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose up to one hour after a meal. If more than one hour has passed since your last meal, skip the dose you missed and take only your next regularly scheduled dose as directed. Do not take a double dose of this medication.

If you miss a meal, or if you have a meal without fat, you can skip your dose of Xenical for that meal also.

What happens if I overdose?

Seek emergency medical attention.

Symptoms of an Xenical overdose are not known.

What are the possible side effects of Xenical?

Stop taking Xenical and seek emergency medical attention if you experience a rare allergic reaction including shortness of breath; closing of your throat; swelling of your lips, tongue, or face; or hives.

Other, less serious side effects are more likely to occur. Continue to take Xenical and talk to your doctor if you experience: oily spotting, gas with discharge, an urgent need to go to the bathroom, oily or fatty stools, an oily discharge, an increased number of bowel movements, an inability to control bowel movements, or orange or brown colored oil in your stool.

The bowel changes listed above are a natural effect of blocking fat and indicate that Xenical is working. They generally occur early in treatment, particularly after meals containing higher amounts of fat than are recommended. These symptoms are usually temporary and lessen or disappear as you continue treatment and keep to your recommended diet of meals containing 30% fat.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect Xenical?

Do not take Xenical without first talking to your doctor if you are taking any of the following medicines: cyclosporine (Neoral, Sandimmune), or warfarin (Coumadin).

You may not be able to take Xenical, or you may require a dosage adjustment or special monitoring during your treatment if you are taking any of the medicines listed above.

Before taking Xenical, tell your doctor if you are taking any of the following medicines to lower cholesterol: atorvastatin (Lipitor), cerivastatin (Baycol), fluvastatin (Lescol), lovastatin (Mevacor), pravastatin (Pravachol), or simvastatin (Zocor).

You may require a dosage adjustment or special monitoring during treatment if you are taking any of the cholesterol-lowering medicines listed above.

Drugs other than those listed here may also interact with Xenical. Talk to your doctor and pharmacist before taking or using any other prescription or over-the-counter medicines.

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